Representative Publications

Click on the publication to read more about the study. Please search for "A. G. Hohmann" on PubMed to view recent publications from this investigator.

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2018

Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase synergize with the opioid analgesic morphine to suppress chemotherapy-induced neuropathic nociception without enhancing effects of morphine on gastrointestinal transit. Slivicki, R.A., Saberi, S., Iyer, V., Vemuri, V.K., Makriyannis, A. and Hohmann, A.G Journal of Pharmacology and Experimental Therapeutics, October 1, 2018.

( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. Liu, Y., Ji, L.; Eno, M., Kudalkar, S., Li, A., Schimpgen, M., Benchama, O.; Morales, P., Xu, S., Hurst, D., Wu, S., Mohammad, K., Wood, J., Zvonok, N., Papahatjis, D., Zhou, H., Honrao, C., Mackie, K., Reggio, P., Hohmann, A., Makriyannis, A. Nikas, S. Journal of Medicinal Chemistry, in press. PMID 30196704.

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. Lee, W.-H., Carey, L.M., Li, L., Xu, Z., Lai, Y.Y., Courtney, M.J. and Hohmann, A.G. Molecular Pain 14: 1-17.

Replay of Episodic Memories in the Rat. Panoz-Brown, D., Vishakh, I., Carey, L.M.,  Sluka, C. M., Rajic, G., Kestenman, J., Gentry, M., Brotheridge, S., Somekh, I., Corbin, H.E., Rucker, K.J., Goncalves, B., Hex, S.B., Garcia, K., Hohmann, A.G., and Crystal, J.D. Current Biology 28: 1-7.

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice. Lee, W.-H., Li, L., Chawla, A., Hudmon, A., Lai, Y.Y., Courtney, M.J. and Hohmann, A.G. Pain 159: 840-863.

Slowly Signaling G Protein-Biased CB2 Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence. Lin, X., Dhopeshwarkar. A., Hubregtse, M., Mackie, K. and Hohmann, A.G. Molecular Pharmacology 93: 49-62.

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence. Slivicki, R., Xu, Z., Kulkarni, P., Pertwee, R., Mackie, K., Thakur, G. and Hohmann, A.G. Biological Psychiatry.

2017

The chemotherapeutic agent paclitaxel selectively impairs reversal learning while sparing prior learning, new learning and episodic memory. Panoz-Brown, D., Carey, L.M., Smith, A.E., Gentry, M., Sluka, C.M.,  Corbin, H.E., Wu, J.-E., Hohmann, A.G. and Crystal, J.D. Society for Neuroscience Abstract Viewer and Itinerary Planner Volume: 47, 429.12.

The cannabinoid system and pain. Woodhams, S.G., Chapman, V., Finn, D.P., Hohmann, A.G. and Neugebauer, V. Neuropharmacology 124: 105-120.

Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice. Li, A., Carey, L.M., Mackie, K., Hohmann A.G. Society for Neuroscience Abstract Viewer and Itinerary Planner Volume: 47, 145.17.

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice. Carey, L.M., Gutierrez, T., Deng L., Lee, W.-H., Mackie, K., and Hohmann, A.G. Scientific Reports 7:944.  Doi: 10.1038/s41598-017-01062-2.

Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats. Carey, L.M., Lee, W.H., Gutierrez, T., Kulkarni, P.M., Thakur, G.A., Lai, Y.Y. and Hohmann, A.G. Neuroscience 349: 303-317.

The chemotherapeutic agent paclitaxel selectively impairs learning while sparing source memory and spatial memory. Panoz-Brown, Carey, L.M., Smith, A.E., Gentry, M., Sluka, C.M., Corbin, H.E., Wu, J.-E., Hohmann, A.G. and Crystal, J.D. Neurobiology of Learning and Memory 144: 259-270

Slivicki, R., Xu, Z., Kulkarni, P., Pertwee, R., Mackie, K., Thakur, G. and Hohmann, A.G. (2017) Positive allosteric modulation of cannabinoid receptor type 1 suppresses pathological pain without producing tolerance or dependence. Biological Psychiatry

2016

Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems. Deng, L., Lee. W.-H., Makriyannis, A. and Hohmann, A.G. Pharmacological Research 114: 75-89.

Source memory in rats is impaired by an NMDA receptor antagonist but not by PSD95-nNOS protein-protein interaction inhibitors. Smith, A., Xu, Z., Lai, Y.Y., Kulkarni, P., Thakur, G., Hohmann, A.G. and Crystal, J.D. Behavioural Brain Research 305: 23-29.

Impact of genetic reduction of NMNAT2 on chemotherapy-induced losses in cell viability in vitro and peripheral neuropathy in vivo. Slivicki, R.A., Ali, Y.O., Lu, H., and Hohmann, A.G. PLOSOne 11(1) e0147620 .

A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase. Carey, L.M., Slivicki, R., Leishman, E., Cornett, B., Mackie, K., Bradshaw, H. and Hohmann, A.G. Society for Neuroscience Abstract Viewer and Itinerary Planner Volume: 45, Abstract: 33.08.

2015

Impact of Genetic Reduction of NMNAT2 on Chemotherapy-Induced Losses in Cell Viability In Vitro and Peripheral Neuropathy In Vivo. Slivicki, R., Ali, Y.O., Lu, H.-C., Hohmann, A.G. Society for Neuroscience Abstract Viewer and Itinerary Planner Volume: 45 Abstract : 797.19

Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Lee, W.H., Xu, Z., Ashpole, N., Hudmon, A., Kulkarni, P.M., Thakur, G.A., Lai, Y.Y. and Hohmann, A.G. Neuropharmacology 97: 464-475.

Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase. Marcus, D.J., Zee, M., Hughes, A., Yuill, M.B., Hohmann, A.G., Mackie, K., Guindon, J., Morgan D.J. Molecular Pain 11:34

CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain. Deng, L., Cornett, B.L., Mackie, K. and Hohmann, A.G. Molecular Pharmacology 88: 64-74.

2014

Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal. Deng, L. Guindon, J., Cornett, B.L., Makriyannis, A., Mackie, K., and Hohmann, A.G. 24th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, Research Triangle Park, NC, USA, page 58.

A lipid gate for the peripheral control of pain. Piomelli, D., Hohmann, A.G., Seybold, V. and Hammock, B.D. Journal of Neuroscience 34(46) 15184-91.

Optimization of a cisplatin model of chemotherapy-induced peripheral neuropathy in mice: use of vitamin C and sodium bicarbonate pretreatments to reduce nephrotoxicity and improve animal health status. Guindon, J., Deng, L., Fan, B., Wager-Miller, J., and Hohmann, A.G. Society for Neuroscience Abstract Viewer and Itinerary Planner Volume: 44 Published 2014-S-15288-SfN.

Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Rahn, E.J., Deng, L., Thakur, G.A., Vemuri, V.K., Zvonok, A.M., Lai, Y.Y., Makriyannis, A. and Hohmann, A.G. Molecular Pain.2014, 10:27

2013

A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. Lynch, M.E., Cesar-Rittenburg, P., and Hohmann A. The 23rd Symposium of the International Cannabinoid Research Society Vancouver, British Columbia, Research Triangle Park. NC, USA,  P4-12.

Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and minimize mortality in rodents receiving the chemotherapeutic agent cisplatin. Guindon, J. and Hohmann, A.G.   Neuroscience Letters 544 (2013) 41-46.

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Guindon, J., Lai, Y., Takacs, S.M., Bradshaw, H.B. and Hohmann, A.G. Pharmacological Research 67: 94-109

2012

Source memory in the rat. Crystal, J.D., Alford, W.T., Zhou, W. and Hohmann, A.G. 42nd Annual Meeting of the Society-for-Neuroscience Location: New Orleans, LA, USA, October 13 -17, 2012 ; Society for Neuroscience Abstract Viewer and Itinerary Planner  Volume: 42

The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. Deng, L., Guindon, J., Vemuri, V.K., Thakur, G., White, F.A., Makriyannis, A. and Hohmann, A.G. Molecular Pain 8: 71

Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. Gregg, L.C, Jung, K.M., Spradley, J.M., Nyilas, R., Suplita II, R.L., Zimmer, A., Watanabe, M., Mackie, K., Katona, I., Piomelli, D. and Hohmann, A.G. The Journal of Neuroscience 32(28) 9457-9468

Rats answer an unexpected question after incidental encoding. Zhou, W., Hohmann, A.G. and Crystal, J.D. Current Biology 22: 1-5

2011

Deng, L., Guindon, J., Makriyannis, A., White, F., Hohmann, A.G. (2011) Paclitaxel and cisplatin-evoked neuropathic pain is suppressed by a cannabinoid CB2 agonist and is independent of CXCR4 signaling. Society for Neuroscience 41th Annual Meeting Abstracts# 2011-S-11218, Washington, DC; 2011-S-15711-SfN, Washington, DC.

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. Sciolino, N.R., Zhou, W. and Hohmann, A.G. Pharmacological Research 64: 226-34.

The endocannabinoid system and cancer: therapeutic implication. Guindon, J. and Hohmann, A.G. British Journal of Pharmacology 163: 1447-63

Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects. Rahn, E.J., Thakur, G.A., Wood, J.T., Zvonok, A.M., Makriyannis, A. and Hohmann, A.G. Pharmacology, Biochemistry and Behavior 98: 493-502

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Guindon, J., Guijarro, A., Piomelli, D. and Hohmann, A.G. British Journal of Pharmacology 163: 1464-78

2010

Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain. Hohmann, Andrea G. In Minicourse: “Synergistic Merge of Operant Conditioning and Chronic Pain Models” 43rd Annual Winter Conference on Brain Research, Breckenridge, Co, January 25, 2010.

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Clapper, J.R., Moreno-Sanz, G., Russo, R., Vacondio F., Duranti, A., Tontini, A., Sanchini, A., Sciolino, N.R., Spradley, J.M., Hohmann, A.G., Calignano, A., Mor, M., Tarzia, G. and Piomelli, D. Nature Neuroscience 13: 1265-1270.

Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Spradley, J.M., Guindon, J. and Hohmann, A.G. Pharmacological Research 62: 249-58.

Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation. Rahn, E.J., Zvonok, A.M., Makriyannis, A. and Hohmann, A.G. The AAPS Journal, 12 (2) 147-157

A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Eisenstein, S.A., Clapper, J., Holmes, P.V., Piomelli, D. and Hohmann, A.G. Pharmacological Research 61: 419-429.

2009

The endocannabinoid system and pain. Guindon, J. and Hohmann, A.G. CNS & Neurological Disorders − Drug Target 8 (6) 403-421 .

Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Rahn, E.J. and Hohmann, A.G. Neurotherapeutics 6: 713-737.

Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. Eisenstein, S., Holmes, P.V. and Hohmann, A.G. Synapse 63: 941-50.

Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. Nyilas, R., Gregg, L.C., Mackie, K., Watanabe, M., Zimmer, A., Hohmann, A.G. and Katona, I. European Journal of Neuroscience 29: 1964-78.

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Anand, P., Whiteside G., Fowler, C.J. and Hohmann A.G. Brain Research Reviews 60: 255-266

2008

Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. Rahn, E.J., Zvonok, A.M., Thakur, G., Makriyannis, A. and Hohmann, A.G. 12th World Congress on Pain, International Association for the Study of Pain, Glasgow, Scotland, 3407.

An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Moise, A.M., Eisenstein, S.A., Astarita, G., Piomelli, D. and Hohmann, A.G. Psychopharmacology 200: 333-346

Cross-sensitization and cross-tolerance between exogenous cannabinoid antinociception and endocannabinoid-mediated stress-induced analgesia. Suplita II, R.L., Eisenstein, S.A., Neely, M.A., Moise, A.M. and Hohmann, A.G. Neuropharmacology 54: 161-71.

2006

Endocannabinoid mechanisms of pain modulation. Hohmann, A.G. and Suplita, R.L. Drug Addiction from Basic Research to Therapy (Springer, NY) pp. 737-764.

Localization of cannabinoid CB1 receptor mRNA using ribonucleotide probes: methods for double- and single-label in situ hybridization. Hohmann, A.G. Methods Mol Med  123: 71-89.

Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Connell, K., Bolton, N., Olsen, D., Piomelli, D. and Hohmann, A.G. Neuroscience Letters 397: 180-184.

2005

Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study. Hohmann, A.G., Neely, M.H., Pina, J. and Nackley, A.G. Journal of Pain 6: 798-808.

A cannabinoid pharmacotherapy for chemotherapy-evoked painful peripheral neuropathy. Hohmann, A.G. PAIN 118: 3-5.

Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: sites of action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. Suplita II, R.L., Farthing, J., Gutierrez, T. and Hohmann, A.G. Neuropharmacology 49:1201-1209.

An endocannabinoid mechanism for stress-induced analgesia. Fegley, D., Neely, M.H., Suplita II, R.L., Holmes, P.V., Crystal, J.D., Piomelli, D., Hohmann, A.G. Society for Neuroscience Abstract Viewer/Itinerary Planner CD-ROM.

2004

Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin. Hohmann, A.G., Farthing, J., Zvonok, A.M. and Makriyannis, A. Journal of Pharmacology and Experimental Therapeutics 308: 446-453.

2003

Cannabinoid modulation of sensitivity to time. Crystal, J.D., Maxwell, K.W. and Hohmann, A.G. Behavioural Brain Research 144: 57-66.

2002

Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives. Hohmann, A.G. Chemistry and Physics of Lipids 121: 173-190.